![]() A benign variant does not cause health problems or disease because the change does not affect how the gene works. Sources to Learn More: What is a genetic variant and how do variants occur? (MedlinePlus) Definition of Variant (NCI) Mutation definition, illustration, and related terms (NHGRI) A genetic variant is a change in a gene's code or DNA sequence that causes the gene to be different than found in most people. Variants that occur in the egg or sperm (germline mutations) can be passed on to offspring, while variants that occur in other body cells (somatic mutations) are not passed on. Variants can result from DNA copying mistakes made during cell division or certain environmental exposures. A pathogenic variant may also be called a mutation or a disease-causing variant. A pathogenic variant does cause health problems or disease because the change does affect how the gene works. Sources to Learn More: What is a gene? (MedlinePlus) What's a Gene? (NHGRI) What are proteins and what do they do? (MedlinePlus)Ī genetic variant is a change in a gene's code or DNA sequence that causes the gene to be different than found in most people. DNA is found in the nucleus of a cell and, in humans, is packaged into 23 pairs of chromosomes with the help of special proteins. Cells are the building blocks of all living things and specialized cells form our body's organs and tissues. Sources to Learn More: What is a gene? (MedlinePlus) What's a Gene? (NHGRI) What are proteins and what do they do? (MedlinePlus) Genes are part of our DNA, the basic genetic material found in each of our body's cells. Others make RNA molecules that are involved in chemical reactions in the body. Some genes can turn other genes on or off. Proteins are needed for the structure, function, and regulation of the body's cells, tissues, and organs. Some genes serve as the instructions to make proteins. ![]() DNA is found in the nucleus of a cell and, in humans, is packaged into 23 pairs of chromosomes with the help of special proteins.Įach gene performs a different job in our cells. Discount is automatically applied.Genes are part of our DNA, the basic genetic material found in each of our body's cells. Standard Gears & Pro Gears Dana / Ford / GM / Mopar.Gears / Diffs / Install Kits Listed By Vehicle.While the 1350 u-joints provide enough strength to handle most demanding of applications, Strange also offers a variety of yokes with1480 u-joints for the ultimate in driveline strength and dependability. The transmission yokes are CNC machined to assure concentricity and balance for ideal driveshaft operation. Strange Engineering’s heavy-duty lines of S-Series transmission and pinion yokes were designed by Strange and are manufactured from USA made high tensile strength nodular iron castings. Transmission Yokes – Strange Engineering’s superior line of Chrome Moly Transmission yokes are manufactured from high quality forgings and fully heat treated to achieve maximum tensile strength.Housing end bolt patterns can be confirmed on the bottom of the axle order form. Axle Retainer plates – Strange engineering offers a variety of steel retainer plates to be used with drum and some disc brake applications.Install Kits and Gears Sets Listed By Rear End.Aluminum Case – Our aluminum cases are manufactured from premium material sourced in the USA, designed and machined in-house, and offered in various forms to meet the requirements of the most demanding applications.
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